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KMID : 0380020100250040387
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Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 4 p.387 ~ p.394
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Effect of Complex Extracts of Mushroom and Sharp Toothed Eel on the Skin Conditions with Atopic Dermatitis and Acne Symptoms
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Cha Wol-Suk
Yoo Ji-Hyun
Min Myung-Ja
Nam Hyung-Gun
Kim Yoon-Soo
Shin Hyun-Jae
Kim Jong-Soo
Choi On-You
Kim Ran
Choi Du-Bok
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Abstract
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This study was conducted to investigate effect of complex extract of various mushrooms and sharp toothed eel on the skin conditions with atopic dermatitis and acne symptoms. The total phenol concentration was increased in order of hot water> ethanol> ethyl acetate> petroleum ether> chloroform extract. Especially, when the hot water extract was used, it was about 2-3 fold higher than that of ethyl acetate, petroleumether, and chloroform extract. When the complex extract concentration was increased from 1.0 to 50 mg/L, the DPPH scavenging rate increased from 10.1 to 81.4%. The reduction power was sharply increased from 0.05 to 0.27 (700 nm) when the complex extract concentration was increased from 25 to 75 mg/L. However, above 100 mg/L, it was not decreased. In the case of SOD-like activity, it was 45.7% at 100 mg/L. Total numbers of patients with atopic dermatitis were 15 and 5 patients with severe acne symptoms. According to photos taken before and after the treatment and questionnaire results, considerable improvements in skin conditions are observed in the patients with atopic dermatitis and acne. For atopic patients, erythema and edema have been improved but the degree of effect was dependent on the individual’s constitution. Concerning acne, the effect of coating of the extracts was prominent for first week and the degree decreased with time till 4 weeks. The complex extracts wereefficient in soothing rash and maturation. Side effects such as a scar were not detected during the application and treatment.
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KEYWORD
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mushroom, sharp toothed eel, antioxidant, atopic dermatitis, acne
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